Hi YC, we’re Natalia Khosla MD and Rachel O’Driscoll from Simbie AI.

TL;DR

Simbie AI is the AI agents’ system for healthcare follow up, ensuring patients get to their next visit. Today 30% of return visits don’t happen because patients get lost in follow up logistics, costing doctors 10% of revenue. Our clinically intelligent, EHR-integrated AI agents proactively reach out to patients and answer their messages, via text and voice, at vulnerable touchpoints for loss to follow up - after new diagnoses, new meds, or diagnostic tests are ordered - and close the loop on every request, documenting directly in the medical chart, until the patient is handed off to their return visit.

Ask: Intros! founders@simbie.ai

https://youtu.be/sobMtQJIwn0

Problem: 30% of patients get lost in follow up and don’t make it to their next appointment

Needing to schedule diagnostic tests like bloodwork or imaging, getting a new med or diagnosis, or general confusion about how to accomplish next steps stop patients from getting there. This loses practices 10% of revenue. Medical groups and hospitals throw expensive people at the problem—sinking 20% of revenue on human staff to chase patients down manually.

Solution: EHR-integrated Clinical AI agents that see patient questions/barriers through to resolution

Beyond reactively answering phones: Simbie AI proactively reach patients at vulnerable touchpoints and get them back on track, answering their responses and scheduling outreach (call & text) sequentially until loops are closed.

Accomplished To Date:

• Grown 400X since launching in Jan 2025
• Used 24/7 in practices across the country
• 0% churn
• 100% inbound, $0 CAC due to our unfair advantages: 1) quick trust-gaining of doctor-leadership as a doctor- and clinical operator-led team and 2) viral spread via physician peer-to-peer networks.

Team & Why:

Natalia and Rachel met during their undergrad days at Yale and have been best friends for 15 years. We are a doctor and clinic operations strategist—this problem is what we each lived for 10 years.

Natalia Khosla MD MSc is a physician from UChicago, Fulbright Scholar, and LSE master’s in health economics. As a doctor herself, and from a family of docs, she has advocated for doctos and their patients throughout her career, recognizing physician burnout and poor patient satisfaction are two sides of the same coin. AI was the turning point she’d been waiting for: infinitely scalable staff to handle the grunt work that depletes doctors and loses patients in the system: making sure no patient is ever lost to follow up again.

Rachel O’Driscoll is a clinical ops and strategy veteran with a proven track record: she built Cayaba Care, a brick and mortar and digital health practice, ground-up. As the Ops leader and de facto practice manager overseeing medical assistants and front desk staff firsthand, she saw the inefficiency of human staffing. Before Cayaba, Rachel led private practice onboarding at Formation Bio and designed partnerships with practices at Carrot Fertility. Across all roles, she’s specialized in streamlining clinic operations, improving patient experience, and building scalable systems that support physician groups and health systems.