Tl;dr: We are Granza Bio, two PhD graduates in Oncology and Immunology from the University of Oxford on a mission to develop personalised and targeted cancer treatments. We are working on a new weapon in our immune system’s arsenal – “attack particles”. We are turning this concept into a therapeutic product that can eliminate any cancer without harming the surrounding healthy cells, preventing adverse side effects.

Hey everyone, we are (Ashwin)²

Team

🧑🏾Ashwin Jainarayanan – Clarendon Scholar and Synthetic Immunologist with extensive research experience on attack particles derived from immune cells.

🧑🏾Ashwin Nandakumar – Cancer biologist specializing in immuno-oncology, who has previously set up clinical trials and brings extensive Oncology start-up experience.

👨🏻‍🔬 Mike Dustin – Professor of Molecular Immunology at the University of Oxford. Widely recognised for his work on immunological synapses and discovered attack particles.

❌ Problem:

~50% of cancer patients receive treatments that are (1) ineffective and (2) lead to unwanted and avoidable side effects.

(1) High mortality rates: Ineffective treatments lead to cancer relapse and ultimately, increased likelihood of dying from cancer. Five-year survival rates are lower than 5% for patients with late-stage cancers including lung, pancreas, and brain cancer.

(2) Toxicity and adverse side effects: While emerging treatments such as immunotherapy and CAR-T cell therapy are effective in some patients, they also impact their healthy tissues. This causes high toxicity and adverse side effects.

✅ Solution: Granza Bio’s cancer-targeting attack particles

We have identified attack particles ⚡: a powerful suite of weapons in our immune system’s arsenal. These attack particles carry proteins like granzymes and perforins that instantly kill cancer cells.

Watch how it works!

📋 Factfile: Granza Bio’s attack particles

• 💀 High cancer-killing efficacy in brain, ovarian, lung, and skin cancers.
• ⚙ Engineered to target only the cancer cells, leaving the surrounding healthy cells untouched, meaning no toxicity or adverse side effects.
• 🧠 Capable of targeting brain cancers by crossing the blood-brain barrier.
• 🎯 Perfectly suited to a platform approach meaning we can use attack particles to target a great range of diseases including cancers, autoimmune diseases, and infections.
• 🏭 Highly stable and easy to manufacture.

Lock & Key method – attack particle targeting cancer

🙏 Our Asks:

• Share this post with your network and help spread the word!
• If you’re as excited as we are about this novel approach to eradicating cancer and would like to learn more about what we’re doing, email us at founders@granzabio.com