Nucleo

The first Agentic platform for Oncology

Chief of Staff to CEO

$60K - $120K0.50% - 1.50%San Francisco, CA, US / Remote
Job type
Full-time
Role
Operations
Experience
Any (new grads ok)
Visa
Will sponsor
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Angelica Iacovelli
Angelica Iacovelli
Founder

About the role

This is an early, high-impact role. You’ll work directly with the CEO and help build the company from the inside.

Job Overview

What you’ll do:

  • Partner closely (on a daily basis) with the CEO on all aspects of running the business.
  • Support the CEO in prioritization, communications, and time allocation to ensure focus on the most critical initiatives.
  • Run weekly exec cadences, project trackers, and help prep internal and external communications.
  • Support go-to-market execution: sales ops, outbound campaigns, deal support.
  • Manage and maintain relationships with hospital customers and partners.
  • Support fundraising: investor pipeline, updates, and diligence prep.
  • Keep visibility on company finances: expenses, vendors, basic accounting.
  • Support regulatory execution (FDA / CE): timelines, documentation, coordination

What You’ll Gain

  • Front-row seat to building a YC-backed deep-tech company from zero to scale
  • Daily exposure to high-stakes decisions: hospitals, regulators, investors, and product all at once.
  • The chance to become one of the core operators of the company, not a support role.
  • Ownership that compounds: the more you deliver, the bigger your scope becomes.
  • A trajectory toward senior leadership as we scale.

About You

  • Proven track record of building/scaling a business/project. We don’t care whether your background is business, technical, or something else.
  • You are based in SF or willing to relocate within this year (we can support O-1).
  • You’re willing to work in person and travel when needed.
  • Proven ability to manage multiple priorities in a fast-paced, dynamic environment. Instinct for early-stage scrappiness & hustle.
  • Strong work ethic & execution velocity.

Nice to have (not required)

  • Experience with hospitals, healthcare procurement, or medical sales.
  • Background in, or passion for, SaaS, AI, or technology companies.
  • Medical training (MD, med student, or formal education in medicine / biomedical sciences).

Pay Range: 60k/yr - 120k/yr + 0.50% - 1.50% equity

This range is based on SF-area data, and is subject to modification based on geographic location.

After applying, please fill out this form.

About Nucleo

Nucleo is an AI-first medtech startup building the first agentic platform for oncology CT scans.

Our mission is simple and ambitious: reduce the time from cancer diagnosis to treatment from ~10 weeks to ~10 days by automating the most time-consuming, manual steps in the clinical workflow.

Today, hospitals still rely on radiologists and oncologists to manually extract critical information from CT scans - body composition, sarcopenia, tumor measurements, RECIST classification. This is slow, expensive, and error-prone. We replace these steps with AI agents that read CT scans end-to-end and generate structured, clinically useful outputs in seconds.

We work with top-tier hospitals in the US and Europe (including Stanford, Cedars-Sinai, UCI Health, and Weill Cornell) and are building toward FDA-cleared clinical software used directly in real oncology workflows.

We operate in a high-ownership, early-stage environment focused on shipping reliable AI into real clinical practice.

Nucleo
Founded:2025
Batch:F25
Team Size:2
Status:
Active
Founders
Angelica Iacovelli
Angelica Iacovelli
Founder
Luca Pegolotti
Luca Pegolotti
Founder